Paraoxonase 1 in Chronic Kidney Failure

Effect of nutritional status on human paraoxonase-1 activity in patients with chronic kidney disease.

BACKGROUND/METHODS The association between nutritional status, antioxidant human paraoxonase-1 (PON1) activity and low grade inflammation in hemodialized (HD) patients with chronic kidney disease (CKD) is unclear. The aim of this study was to determine PON1 paraoxonase and lactonase activities, ADMA, adiponectin and leptin concentrations, and to clarify the relationship between paraoxonase acti...

Decrease of serum paraoxonase activity in chronic renal failure.

Paraoxonase is an esterase that hydrolyzes organophosphate compounds. The enzyme is associated with HDL and could protect LDL against peroxidation, which suggests a possible involvement of paraoxonase in the antiatherogenic properties of HDL. Paraoxonase activity has been shown to be low in patients with myocardial infarction, diabetes mellitus, or familial hypercholesterolemia. Because cardiov...

Low high-density lipoprotein cholesterol is not responsible for decreased paraoxonase activity in chronic renal failure.

BACKGROUND/AIMS Human paraoxonase-1 (PON1) is responsible for the antioxidant effect of high-density lipoprotein (HDL) by inhibiting low-density lipoprotein oxidation. Previous studies discovered dyslipidemia (DL) and decreased PON1 activity in chronic renal failure (CRF). We aimed to determine PON and arylesterase activity, phenotypic distribution of the PON1 enzyme, and lipid profile in low a...

Changes of PON1 paraoxonase and lactonase activities in hemodialysis and renal transplant patients

Serum Cystatin C Is a Determinant of Paraoxonase Activity in Hemodialyzed and Renal Transplanted Patients

BACKGROUND Human paraoxonase-1 (PON1) inhibits LDL-oxidation and atherogenesis, and possesses lactonase activity. Decreased PON1 activity was found in hemodialyzed and renal transplanted patients. Cystatin C plays a protective role in atherosclerosis, and is a new, sensitive marker of renal function. The relationship between these two markers in renal failure has not been investigated. AIMS T...

Ph.D. THESIS FATTY LIVER, OBESITY AND HEPATOCELLULAR CANCER: IMPACTS OF UNCOUPLING PROTEIN-2 AND FLUVASTATIN

s of peer-reviewed oral and poster publications: Tóth A, Fülöp P, Csortos C, Gergely P, Erdõdi F. Purification and identification of protein phosphatase with type-specific antibodies. 1 Scientific Conference of the Hungarian Biochemical Society Molecular Biology Group, Seregélyes, Hungary, 1996 Katona E, Seres I, Balogh Z, Fülöp P, Kakuk G, Paragh G. Changes in the serum paraoxonase activity of...